Antidiabeticeffectsoftheethanolicrootextractof uvaria. Beav annonaceae methanol root bark extracts were tested in vivo and in vitro. Species are distributed throughout the old world tropics. The nmr was similar new benzyldihydrochalcones from uvaria chamae 1593 to that of chamuvarin in having a 2hs at 3. All structured data from the file and property namespaces is available under the creative commons cc0 license. Uvaria chamae is a medicinal plant that is used in many parts of the world in the treatment of diabetes, and other diseases. The efficacy of uvaria chamae plant species in herbal remedies may have come as a result of. Chamuvaritin 20 is a dihydrobenzylchalcone isolated from uvaria chamae, an african medicinal plant used as purgative and febrifugal 38.
Their constituents were extracted and then fractionated in order to isolate the active ingredients. Two known polyoxygenated cyclohexene derivatives, ferrudiol and zeylenol, and a new analog. The antifungal, antimalarial and antiinflammatory activities of uvaria chamae have also been reported 11, 14. Odewo, a taxonomist in the department of botany and microbiology, faculty of science, university of lagos, nigeria. Studies on the antiulcer properties of ethanolic leaf.
Toxicological studies of herbal antitumor extract uvaria. Phytochemical composition and antimicrobial activity of the. Their antiinflammatory and oxytocic properties were assessed in this study. The generic name uvaria is derived from the latin uva meaning grape, likely because the edible fruit of some species in the genus resemble grapes. Uvaria chamae in the germplasm resources information network grin, u. Beauv and clerodendron splendens a cheval are known to have various medicinal and therapeutic properties. Antiglycation, antioxidant, and cytotoxic activities of uvaria chamae. Pdf in vitro antisickling activities and phytochemical. Uvaria is a genus of flowering plants in the soursop family, annonaceae. Usda, ars, germplasm resources information network. Documentation of wound healing plants in lagosnige ria. Department of plant science and biotechnology, michael okpara university of agriculture, umudike p. The various vernacular names mostly cover more than this one species.
The ld50 done in albino mice 20 25g showed safety margin above 5000mgkg. However, no scientific study has been conducted on the antidiabetic activity of this plant. Pdf toxicological studies of herbal antitumor extract uvaria. These consist mainly of essential oils, flavonoids, alkaloids and annonaceous acetogenins. Medicinal plants are the local heritage with global importance. Uvaria chamae, commonly known as finger root or bush banana belongs to the family annonaceae. The drug benzyl benzoate used in antifungal preparations has a mutagenic compound, chamuvaritin, a benzyl dihydrochalcone that was isolated from uvaria chamae 10. Nov 15, 2016 the study showed that the hypoglycemic properties of uvaria chamae may be accounted for by the presence of the phytochemicals. Phytochemical composition and antimicrobial activity of the leaves of alchornea cordifolia schum and thonn, sanseviera liberica gerand labr and uvaria chamae p.
Antidiabeticeffectsoftheethanolicrootextractof uvaria chamae. Pdf antibacterial activity of chalcone and dihydrochalcone. Pdf phytochemical composition and biological activities. Uvaria chamae root extract revealed the presence of saponnins, cardiac glycosides and terpenes tab. Uvaria chamae exhibited inhibitory activity table 2. The plant material was defatted with nhexane and 70% methanol. In vitro antiradical and antisalmonella activities of. Uvaria chamae was extracted with ethanol, and administered orally to rats at doses ranging from 200 to 5000 mgkgday for 28 days while distilled water was administered to the control group, the survived animals 43 %, were then euthanized, and blood collected for biochemical and haematological markers. Pdf phytochemical composition, antioxidant and antibacterial. This study aims to analyze the chemical compounds and evaluate the antiradical and antisalmonellaactivities of extracts from sarcocephalus latifolius, lannea barteri, uvaria chamae, parkia biglobosaand khaya senegalensis using respectively standards phytochemical methods, phosphomolybdates reduction method and micro dilution method in liquid medium associated with plating on agar medium. Evaluation of invivo anti salmonella activity of uvaria.
The potentials of uvaria chamae as an antidiabetic and hypolipidemic drug candidate are thus tested. Uvaria chamae on the kidney of albino rats, by measuring the levels of some electrolytes. Uvaria chamae annonaceae, phyllantus amarus phyllantaceae and lantana camara verbenaceae are empirically alleged to be used as beninese medicinal plants in the treatment of salmonellosis. Antidiabetic effects of the ethanolic root extract of. Files are available under licenses specified on their description page. Pdf comparative assessment of antibacterial activity of. This finding indicates the anticaries potentials of these plant extracts and their probable implication in the management of dental caries. Filed as uvaria chamae beauvais family annonaceae syntype of uvaria cylindrica schumach.
The ld 50 value of the mice treated intraperitoneally with a single dose of 0. Antibacterial activity of extracts of plant was evaluated on four bacterial strains e. Phytochemical composition and biological activities 555 preparation of plant extracts the leaves of clerodendron splendens and roots of uvarea chamae were airdried at the laboratory bench for 10 days and then ground into a uniform powder using a thomas wiley mill machine model ed 5 usa. The ethanolic extracts were tested for antiulcer activities uchamae showed a better anti ulcer activity on albino wistar rats compared tocimetidine a. This study presents antimicrobial properties of uvaria chamae roots, commonly used for the treatment of various infections in south benin. Issued as a pdf on the internet, it contains basic information on over 250 species of plants used for food. Two new cbenzylated flavanones from uvaria chamae and c. Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to. The common name refers to the fruit growing in its small bunches. Antidiabetic effects of the ethanolic root extract of uvaria chamae p. A report has suggested a relationship between the free radical scavenging activity. Access is allocated within two business days of purchase and lasts one year. Chamuvarinin, an acetogenin bearing a tetrahydropyran ring. Monosodium glutamate, uvaria chamae, tamoxifen, tumor markers, necrosis.
Phytochemical composition and antimicrobial activity of. Uvaria chamae is a climbing shrub or small tree growing up to 4 metres tall328. The implication of these results is in defining the role of each plant specimen in traditional recipes for scd management and drug development is presented. A new cytotoxic acetogenin, chamuvarinin 1, containing a tetrahydropyran ring with an adjacent bistetrahydrofuran ring, which corresponds to a novel carbon skeleton in this series, was isolated from the roots of uvaria chamae, together with the previously reported acetogenins squamocin 2, desacetyluvaricin 3, and neoannonin 4. Uvaria chamae, commonly known as finger root or bush banana is a climbing large shrub or. Table 2 is a summary of the results of the effects of uvaria chamae on plasma lipid profile in diabetic rats. Uvaria chamae, commonly known as finger root or bush banana is a climbing large shrub or small tree native to tropical west and central africa where it grows in wet and dry forests and coastal scrublands. Phytochemical screening and effect of ethanolic root extract. Antihemolytic properties of extracts of six plants used in. A novel 1indanone isolated from uvaria afzelii roots. The plasma cholesterol and ldl levels of diabetic rats treated with the extracts were significantly reduced p free media repository. Cytotoxic cbenzylated chalcone and other constituents of. Methods aqueous macerated leaves of uvaria chamae identification and leaf powder of uvaria chamae the botanical identification was carried out at the national floristic center of the university felix houphouet boigny ivory coast. Pdf phytochemical composition and biological activities of uvaria.
Diabetes mellitus has been a menace to mankind from time immemorial. This study aimed to produce scientific data on in vitro and in vivo efficacy of uvaria chamae, lantana camara and phyllantus amarus on multiresistant salmonella spp isolated in benin. Macro elemental composition of uvaria chamae leaves. Review of literature phytochemical screening medicinal plants are best owed with large number of pharmaceutically useful compounds which can be studied for investigation of new drugs for many serious diseases like cancer, tumours, aids and many human degenerative diseases. Evaluation of invivo antisalmonella activity of uvaria.
The extracts and aspirin were found to inhibit carrageenaninduced paw oedema on albino rats and mice with a strong activity in aspirin having 80. Pdf a novel 1indanone isolated from uvaria afzelii roots. Phytoconstituants of two extracts of uvaria chamae tannins, flavonoids, and. Leaves aqueous extract of uvaria chamae was bacteriostatic on salmonella typhimurium atcc 14028 and salmonella spp. Phytochemical screening and effect of ethanolic root. Methanolic extracts of the root, stem and leaf of uvaria chamae were evaluated for their antibacterial activity against methicillinresistant staphylococcus aureus mrsa, staphylococcus aureus, escherichia coli, klebsiella spp, proteus spp, and. In vivo antisalmonella activity of aqueous extracts leaves of uvaria chamae using chick models preliminary test. Antiinflammatory activity of the aqueous macerate of leaves. Antimicrobial susceptibility tests were performed against several multidrugresistant bacteria using the mueller hilton well agar diffusion method.
Uvaria chamae is one of such plants used traditionally to treat diabetes. For antioxidant property, free radicals scavenging capacity of the two extracts. In the present work phytochemical composition, antioxidant and antibacterial properties of aqueous and ethanol extracts of root of uvaria chamae were studied. Odewo, a taxonomist in the department of botany and microbiology, faculty of.
Sep 29, 2011 madubunyi ii 2010 hepatoprotective activity of uvaria chamae root bark methanol extract against acetaminopheninduced liver lesions in rats. This phytochemical was mutagenic in salmonella typhimurium strains ta98 and ta100 via the activation by the hepatic microsomal enzyme preparation. Antidiabetic and hypolipidemic activities of hydroethanolic root. The potentials of uvaria chamae as an antidiabetic and hypolipidemic drugcandidate are thus tested. Apart from saponins, all the other groups of compounds were revealed by the current phytochemical screening. Uvaria chamae is a plant with both medicinal and nutritional values. Department of agriculture agricultural research service. Antiinflammatory activity of the aqueous macerate of. The roots of the plants were collected in the esan central region of edo state, nigeria. Methanolic extracts of the root, stem and leaf of uvaria chamae were evaluated for their antibacterial activity against methicillinresistant staphylococcus aureus mrsa, staphylococcus aureus. Finding the best college admission essay help shouldnt be a big deal once you can fully understand the tips my immigration story essay of. Phytochemical composition, antioxidant and antibacterial.
Macro elemental composition of uvaria chamae leaves with abstract, chapter 15, references and questionnaire. Evaluation of uvaria chamae aqueous and ethanolic extracts. Beauv revealed the presence of bioactive compounds consisting of flavonoids, alkaloids, tannins, saponins and phenolic compounds. For the extraction of the phenolic constituents, the fat free sample was boiled with. Antidiabetic effects of the ethanolic root extract of uvaria. The study aimed at evaluating antidiabetic activity of the ethanolic root extract of u. The two extracts of plant showed significant p free radical.
Please note that this is a trial program and may end. Antisickling activity, phytochemicals, plumbago zeylanica, sickle cell disease, uvaria chamae. Title african flowering plants database publication author website. Free radical scavenging activity was evaluated using 2,2diphenyl1 picrylhydrazyl dpph radicals and inhibition of lipid peroxidation was accessed with thiobarbituric acid tba. In this study, we evaluated the acute and subchronic oral toxicity and safety of the aqueous root extract of uvaria chamae in spraguedawley rats. Media in category uvaria chamae the following 2 files are in this category, out of 2 total.
Isolation and characterization of compounds from the stem bark of uvaria rufa annonaceae 53 experiments of hmbc as shown in a and hh cosy in b established the final structure of benzyl benzoate. We assure you that the result will be worthy of your time and money. Pdf phytochemical composition and biological activities of. Beauv annonaceae offers alternative treatment for diabetes mellitus. However, research is needed to ascertain the beneficial and adverse effects of the consumption of the extract. The fruit carpels are in fingerlike clusters, the shape giving rise to many vernacular names translated as bush banana or the like implying wildness. Antidiabetic and hypolipidemic activities of hydroethanolic. Phytochemical composition and biological activities of uvaria. In tables 2 and 3, the antisickling activities glycosides is an indication that a recipe that contain u. This study aims to analyze the chemical compounds and evaluate the antiradical and antisalmonellaactivities of extracts from sarcocephalus latifolius, lannea barteri, uvaria chamae, parkia biglobosaand khaya senegalensis using respectively standards phytochemical methods, phosphomolybdates reduction method and micro dilution method in liquid medium associated with. At a concentration of 400mgml the extracts of phyllanthus amartes and uvaria chamae produced zone diameter izd of 1 1 mm and 8mm respectively. Two known polyoxygenated cyclohexene derivatives, ferrudiol and zeylenol, and a new. Antibacterial parameters revealed that among the four bacteria tested, aqueous extract of uvaria chamae has bacteriostatic power against esbl strains mbcmic 16. Some of these biologically active secondary metabolites validate the claim made in traditional system of medicine.
Uvaria chamae annonaceae, is an essential oil bearing plant. African journal of biotechnology in vitro antisickling. New benzyldihydrochalcones from uvaria chamae sciencedirect. The leaf extract of the plant uvaria chamae family annonoceace was extracted with 70% ethanol, and the ethanolic extract were tested for antiulceractivities. Their absence could be justified by the nature of the. It has been reported that extracts of uvaria chamae have mutagenic effects. Introduction free glutamate and bound with other amino acids into.
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